challenging! i think a separate toilet and vanity area and bath/laundry works better and allows for multiple person occupancy but, measurements are critical so, a toilet shortest front to back leaves more leg room and an extra big drop in handbasin would look best in the bathroom instead of a laundry tub and what about an old fashioned shower curtain instead of a glass screen if you like the big bathtub with shower instead of a walk in super wide shower with glass screen. The scale of the laundry/bath wall cabinets will fit best (and have more storage for linen, laundry supplies and shampoo etc) if you use a 30cm deep kitchen wall cabinet (with mirror doors) instead of the usuall medicine cabinet depth The tall skinny cabinet in the vanity area should just fit an ironing board and skinny vacuum cleaner with linen under the small drop in (makes the bench more spacious) handbasin ...The doorway into the vanity area has no door, although an in-wall slider would be OK coming from the toilet side, a swinging door would just be in the way...the two windows in the bathroom are placed to maximise ventilation and should be no more than 75cm wide and 120cm tall (frosted glass?) Careful choice of fittings should have everything fitting in OK, good luck with it

If the rumpus is going to be used as a family day care room, then I think the powder room should be accessible from there. This will make it so much easier for one person to supervise the kids in the room as well as the one who is heading off to the toilet. Perhaps you also need a wet area in there for cleaing up after messy activities. I know someone with a similar family day care set up, and they have toilet and laundry attached to the back of the garage/daycare space. And then the kitchen is adjacent, this makes life a lot easier for the sole person in charge of the kids.

you need to confirm all the dimensions as there's some discrepancies in the sizes shown in your plan but my suggestions include losing the linen cupboard in favour of a bigger bathroom with space for full size bath, shower, vanity and toilet with linen storage in the vanity under the handbasin and toiletries in wide wall cabinets over the sink and toilet...there's a sliding glass door off the kitchen to an enlarged deck and a galley kitchen with old laundry becoming a combination laundry and pantry with wide counter for under bench washer and blind corner pantry and space for the fridge and removing only portion of the wall allows for an opening between kitchen and living with space leftover for stove, counter, drawers and wall cabinets and more counter with double sink, DW and drawers on the other side

Question only you can answer. Why did you want the big laundry in the first place? Would a euro laundry be sufficient for your household.? For occasional guests would the specific guest bedroom be an unused space for great lengths of time. A laundry is used every day. I suppose you can store the brooms,vacuum, ironing board, in the guest suite.....